“But what they were doing in the nucleus separate from membranes was a mystery.” “We have known for some time that lipid messenger molecules that activate the PI3K/Akt pathway found in membranes are also present in the nucleus of cells,” says Anderson, a professor at the UW School of Medicine and Public Health. The findings, published today in the journal Nature Cell Biology, identified links in the pathways that make promising targets for new cancer treatments. Anderson and Vincent Cryns has discovered a direct link between the p53 and PI3K/Akt pathways.
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The process is a bit like sending mail, which requires a specific series of steps and appropriate stamps and marks on the envelope to deliver a letter to the correct address.Ī team led by UW–Madison cancer researchers Richard A. Mutations activating a cellular pathway called PI3K/Akt, located on the surface of cells, are also often implicated in runaway cell growth in cancer.Ĭellular signaling pathways allow cells to accomplish important communications tasks that maintain healthy cell functions.
Understanding their cooperative effects may lead to more effective treatments.Ĭells muster a protein, called p53, which acts inside the cell nucleus to respond to stress, but mutations of the gene that produces p53 are the most frequent genetic abnormalities in cancer.
To date, researchers have focused on finding drugs that block one or the other to treat cancer. MADISON - Two of the most common genetic changes that cause cells to become cancerous, which were previously thought to be separate and regulated by different cellular signals, are working in concert, according to new research from the University of Wisconsin–Madison.
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